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Historically, Copper Acetate Manufacturers(WSDTY) proposed copper acetate compounds have been used as paint pigments, wood preservatives and pesticides. Copper compounds are also used as actives or excipients in cosmetic and pharmaceutical products, e.g., copper peptide for skin regeneration purposes, cupric aspirinate and cupric salicylate for rheumatoid arthritis treatment, copper conjugated dendrimer for anti-tumoral activity, and copper liposome for enhanced stability of doxorubicin5,6,7,8,9. Copper can also be used in photo-thermal nanoparticles. These copper nanoparticles-mediated drug delivery systems can significantly increase the permeability of drug and enable controlled transdermal drug delivery10.

With developments in novel skin permeation enhancing methods such as microneedles and laser, copper compounds can potentially be used on skin for cosmeceutical or medicinal purposes5,11,12. Efficacy and safety studies are equally important for the successful development of such delivery systems. However, many current studies are primarily focused on improving the pharmacodynamic and pharmacokinetic properties of copper, while data on copper-induced dermal toxicity remain limited. Along with wide exposure of copper on the skin or mucosa, incidences of contact dermatitis have been reported although not frequently. For instance, a woman who reported a 5-year history of painful lichenoid lesions on the left mucosa and on the left side of the tongue adjacent to a dental metal prosthesis containing copper, had all these symptoms relieved after the prosthesis was substituted to one without copper. Dermatitis and eczematous rash were also reported by individuals who used IUD. Hand eczemas were commonly reported among cashiers and other professionals handling coins, which may be caused or aggravated by the release of metal ions including copper3. In essence, sources of copper-induced irritations can range from occupational exposures to copper-based items to copper-based pesticides, resulting in allergic reactions, such as itching and eczema13.

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